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    Downstream Processing: Ultrafiltration and Diafiltration

    Describes the downstream manufacturing processes of ultrafiltration and diafiltration with an emphasis on post-harvest volume reduction and concentration for therapeutic protein products. The components of an UF/DF skid and control of the UF/DF process are also described.

    Whether for onboarding or annual refresher training, this Module is seamlessly deployable on any LMS and can be tailored to your company’s exact needs.

      Duration: 30 Mins

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    SKU: BPU-1102-SPL03-EN Category: Tag:

    Description

    Learning Objectives:

    • Explain the role of filtration in protein purification methods
    • Describe the role of ultrafiltration / diafiltration (UF/DF) in downstream processing
    • Describe the difference between Normal Flow Filtration (NFF) and Tangential Flow Filtration (TFF)
    • List the advantages of TFF over NFF
    • Explain the terms molecular weight cut off and transmembrane pressure
    • Identify important components of a UF/DF skid and their functions
    • List and explain the critical process parameters involved in a UF/DF operation
    • Describe the in-process checks and quality tests that are carried out during a UF/DF operation
    • Describe how a UF/DF skid is cleaned
    • Describe the safety requirements associated with UF/DF
    • List some common problems encountered when operating UF/DF

    Learner Benefits:

    • Gain in-depth knowledge of the role of ultrafiltration and diafiltration in protein purification, including the differences and advantages of normal flow and tangential flow filtration.
    • Enhance your technical vocabulary and understanding of key terminology such as molecular weight cut-off, transmembrane pressure, retentate, and permeate.
    • Explore the components of UF/DF skids and their functions.
    • Identify critical process parameters and understand the role of in-process checks, quality tests, and troubleshooting during UF/DF operations.
    • Gain practical knowledge of the set-up, operation, and cleaning of ultrafiltration and diafiltration systems.
    • Understand the safety requirements associated with UF/DF operations and learn how to maintain high standards of cleanliness and integrity in biopharmaceutical manufacturing environments.
    		 Module Features:

        Animations
       Voice Over
        Knowledge Checks
        Assessments
       SCORM/AICC compatible
        Full Screen

     

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