Distillation & Reflux
The principles of distillation and reflux, focusing on their roles in active pharmaceutical ingredient (API) manufacturing. Learners will explore the underlying processes of these separation techniques, including how they function to isolate and purify substances. The module highlights critical parameters for controlling both distillation and reflux, ensuring safety, efficiency, and product quality. Key topics include the distinction between distillation and reflux, the purpose of fractionating columns and reflux condensers, and the importance of managing critical process variables such as temperature, time, and solvent levels.
Whether for onboarding or annual refresher training, this Module is seamlessly deployable on any LMS and can be tailored to your company’s exact needs.
 Duration: 30 Mins
Grade: Core Library
Description
- Understand Distillation and Reflux Principles: Learn the basic processes of distillation and reflux, including how vaporization and condensation are used to separate or recycle liquids in pharmaceutical manufacturing.
- Gain Knowledge of Process Control: Discover how to identify and manage key parameters such as heating, cooling, vacuum, and time to support effective distillation and reflux processes.
- Follow Safety Precautions in Separation Processes: Understand important safety precautions for operating distillation and reflux systems to help protect both personnel and product quality.
- Gain Practical Insights into Equipment Usage: Get to know the purpose and function of equipment like fractionating columns and reflux condensers, and how they support efficient and effective processing.
- Optimize Processes and Address Issues: Learn how to monitor and adjust process variables to improve yields, minimize risks, and recognize signs of equipment malfunctions or process deviations.
Learning Objectives
- Define distillation and reflux as they relate to API manufacturing.
- Explain the difference between distillation and reflux in API manufacturing.
- Compare evaporation and distillation.
- Explain the difference between first and second fractions in distillation.
- Describe the purpose of a fractionating column.
- List the critical process variables of distillation.
- Describe the purpose of a reflux condenser.
- List the critical process variables of a reflux process.
- Recognize the importance of safety in distillation and reflux processes, and the necessary operator PPE.
Keywords
- Active Pharmaceutical Ingredient (API)
- Boiling Point
- Cooling
- Condenser
- Distillation
- Evaporation
- Fractionating Column
- Fractional Distillation
- Heating
- Liquid
- Reflux
- Reflux Condenser
- Safety
- Solvent Level
- Time
- Vacuum
- Vapor
- Visual Checks
Module Features
  Animations
  Voice Over
  Knowledge Checks
  Assessments
  SCORM/AICC compatible
  Full Screen
