Understanding Dissolution

• Define the term ‘dissolution’
• Explain the purpose of dissolution testing
• List and describe the factors that affect dissolution
• Describe what happens to a solid dosage drug form in the human body after it is swallowed
• Explain the difference between ‘in vivo’ and ‘in vitro’ dissolution analysis
• Explain why in vitro dissolution analysis is important
• Explain the difference between single-point and multi-point dissolution tests

Learner Benefits:

• Clear Comprehension of Dissolution Fundamentals: Master the definition and essential purpose of dissolution, including the physical and chemical processes that influence how drugs dissolve.

• Insight into Critical Testing Parameters: Recognize the factors impacting dissolution, such as solvent polarity, temperature, pH, and stirring, enhancing your understanding of formulation behavior in various environments.

• Practical Understanding of Drug Absorption: Learn how a solid dosage form disintegrates and dissolves in the gastrointestinal tract before crossing into the bloodstream, crucial for assessing bioavailability.

• Differentiation Between Analytical Techniques: Distinguish between ‘in vivo’ and ‘in vitro’ testing, appreciating the importance of simulating human conditions in laboratory settings to predict drug performance.

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    Assessments
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